Develop new research and diagnosis solutions to address resistant infections
Alcimed Healthcare’s team is exploring the global health crisis of antibiotic resistance, as part of the efforts to address antimicrobial resistance, helping their clients create new treatment and diagnostic approaches, understand public health challenges and penetrate different geographies.
THE Challenges related to antibiotic resistance
What is antibiotic resistance and antimicrobial resistance?
Antibiotic resistance is the ability of a bacterium to develop defense mechanisms that allow it to escape the action of an antibiotic drug.
While bacteria represent the highest priority category of drug-resistant microbes, other types of microorganisms such as viruses, fungi, and parasites, can be unresponsive to drugs, resulting in antimicrobial resistance (AMR).
What are the main challenges related to antibiotic resistance?
Antibiotic resistance is considered a global health crisis, with some stakeholders referring to it as the next pandemic. With 1.27 million deaths worldwide in 2019, the death toll is rising and is estimated to cause up to 10 million deaths per year by 2050.
This antibiotic resistance leads to the inability to treat and control the disease caused by an infection. The impact on human health is directly related to antibiotics use, but also indirectly related to the consumption of antibiotics used for health and growth in agriculture and livestock.
Low- and middle-income countries are particularly affected by resistant bacteria, which are considered a top priority from a medical perspective.
Pharmaceutical and MedTech companies, as well as public organizations and alliances, must be united and work together to control this global public health threat. But these companies and organizations face many challenges, such as low profitability of antibiotics, stewardship, and market access difficulties.
Multiple guidance strategies are proposed to provide the correct doses of drugs, know when to prescribe antibiotics, and know when to discontinue antibiotic use to limit the development of bacteria resistant to our current treatments.
How to optimize antibiotics use? How to raise awareness and develop therapeutic and medical education on antibiotic resistance and antibiotics usage? Which tool? Which channel?
The lack of innovative solutions in this area results in a limited number of new antibiotics coming to market, which compromises their effectiveness. On average, antimicrobial resistance is reported for most new agents two to three years after they are introduced to the market.
New antibiotics, sometimes from start-up companies, face difficulties related to the requirements of the agencies regulating marketing authorizations, as well as to the lack of appropriate business models that allow for sufficient profitability. This has led to a succession of failures and a lack of interest from industry. Ultimately, even if new antibiotics do reach the market, they may only reach the third line of treatment and are therefore rarely prescribed.
Besides, to date, we do not have many methods to prevent the development of antimicrobial resistance (AMR). Fundamental research, empowered by data science probably, is needed to develop predictive models to resistance development.
What are the innovative funding mechanisms for antibiotic R&D? How to develop a profitable case with a new antibiotic? Can AI help in the discovery of new antibiotics or in the prediction of antibiotic resistance?
Joint efforts are being made by public and private organizations to combat antibiotic resistance. Communication, management and organization are not necessarily in place and need to be defined, which may vary by country and antibiotic.
For example, the One Health initiative, created in 2000, promotes an integrated, systems approach to human, public, animal, and environmental health at the local, national, and global levels to combat emerging illnesses with pandemic potential, including antibiotic resistance.
Their primary focus is to provide guidelines for mitigating this crisis, given the differences in regulation, access, and stewardship already in place depending on the geography.
How are public organizations helping with resistant bacteria? What global health initiatives exist to contrast antibiotic resistance that could be leveraged?
Antibiotics are used on animals and in agriculture to prevent and treat diseases caused by bacterial infections, as well as to rapidly increase the growth of animals. The pressure of mass production of livestock and agriculture therefore leads to unnecessary overuse of antimicrobials drugs.
Even if in some countries the use of antibiotics as growth promoter is banned, guidelines and restrictions on the use of antibiotics for animal health and agriculture should be developed and implemented globally.
What are the effective alternatives to antibiotics for rent animals and for plants? What kind of agricultural practice or setting can help in reducing the antibiotic use?
How do we support you in your antibiotic resistance or antimicrobial resistance projects?
For over 25 years, Alcimed has accompanied its clients in multiple explorations in healthcare, notably related to antibiotic resistance and new antibiotic approaches. We have conducted 50+ projects in the context of infectious diseases and antibiotic resistance.
The players we have helped with our explorations include:
- Pharmaceutical companies to position their existing products in new infectious diseases, or to investigate new opportunities with products in development
- Non-profit and private organizations to better understand the market of antibiotics for different indications and geographic areas
The importance of antibiotic resistance around the world has allowed our team to explore its impact globally, while investigating the key differentiating elements in each country or region. Thanks to our wide range of clients, as well as our exploration of various geographical fields and project types, we have gained a comprehensive and global understanding of the issues surrounding antibiotic resistance.
Our projects include, amongst others, exploration of products and new technologies, assessment of the state of the art of products, specific market studies, business case development, mapping of programs and ecosystems, market access strategies, deciphering care pathways or agricultural practices in any geography.
For more information on the key challenges related to antibiotic resistance and how innovation can help address this global health crisis, check out our position paper on antibiotic resistance!
EXAMPLES OF RECENT PROJECTS CARRIED OUT FOR OUR CLIENTS IN ANTIBIOTIC RESISTANCE
Our purpose? Helping both private and public decision-makers explore and develop their uncharted territories: new technologies, new offers, new geographies, possible futures, and new ways to innovate.
Located across eight offices around the world (France, Europe, Singapore and the United States), our team is made up of 220 highly-qualified, multicultural and passionate explorers, with a blended science/technology and business culture.
Our dream? To build a team of 1,000 explorers, to design tomorrow's world hand in hand with our clients.
- Proof of concept
- Voice of Customer (VOC)
Identify and analyze the practices of other players with a benchmark
- Business case
Validate your project launch with a business case
- Climate resilience and adaptation to climate change
Improve your resilience in the face of climate change
- Customer experience
Improve your customer satisfaction by working on your customer experience
Combine energy performance and industrial performance
- Diversification strategy
Expand your business with a diversification strategy
- Market Access
Develop a strong and distinctive market access strategy
- Market Study
Analyze and understand how a market really works thanks to market study
- New services
Enrich your offer by developing new innovative services
- Opportunity evaluation
Measure the attractiveness of a business by conducting an opportunity assessment
- Patient pathway
Innovate and reinvent patient care pathways
- Product innovation
Imagine the innovative products of tomorrow by boosting your product innovation
- Product launch
Succeed in your product launch with a robust sales and marketing strategy
Optimize your supply and production sources and accelerate your ecological transition by relocating your activities
Structure your project launch with a roadmap
- Strategic audit
Make a strategic audit of your business
- Strategic positioning
Stand out from the competition with the right positioning strategy
- Business development
- Business models
- Business plan
- Cluster study
- Collaborative projects
- Commercial strategy
- Competitive analysis
- Dossier creation
- Due diligence
- Go to market
- Innovation consulting
- Innovation process
- Innovation strategy
- Learning expedition
- New offers
- Open innovation
- Regulatory framework analysis
- Search for funding opportunities
- Search for partners
- State of the art
- Strategic foresight
- Test and Learn
- Value proposition